“Computational studies of bacterial chemoreceptors: from cell biology to signaling mechanism”
Igor B. Jouline (Zhulin)Distinguished ScientistComputing & Computational Sciences DirectorateOak Ridge National LaboratoryJoint Faculty ProfessorDepartment of MicrobiologyUniversity of Tennessee-Knoxville
Bacterial chemoreceptors are widely used as a model system for elucidating the molecular mechanisms of transmembrane signaling and have provided detailed understanding of how ligand binding the receptor modulates the activity of associated kinase. This signaling pathway is analogous to ubiquitous signaling pathways in eukaryotic cells that are anchored by G-protein coupled receptors.In this talk, I will show how various computational biology approaches combined with a wealth of knowledge obtained by experimental techniques (from classical genetics and biochemistry to X-ray crystallography and cryoelectron tomography) lead to new advances in understanding signal transduction mechanisms.
Thu, January 23, 2014
02:00 PM - 03:00 PM