UTHSC Calendar
Why don't transcription factors get lost?

Barack Cohen, PhD


Associate Professor


Dept. of Genetics


Washington University School of Medicine


St. Louis, MO 


 

Brief Abstract: Large mammalian genomes contain millions of copies of the short, degenerate sequence motifs that recognize sequence specific DNA binding proteins. However, data from large scale studies of transcription factor binding studies show that only 1 in every 1000 potential sites are occupied in vivo. How is this specificity achieved. Two hypotheses have been put forward to explain this observation. One hypothesis states that the chromatin environment plays an instructive role in determining which transcription factor binding sites are bound and which are ignored. A second hypothesis is that local primary DNA sequence features distinguish functional from non-functional sites. I will discuss experiments in our lab that aim to distinguish between these two hypotheses.
Wed, October 2, 2013
01:00 PM - 02:00 PM

Categories:
  • Campus Wide Event

  • Dentistry

  • Graduate Health Sciences

  • Medicine

  • Nursing

  • Pharmacy

  • Research

  • UTHSC Home Page


  • Location:   Map    Weather  
    Cancer Research Building Auditorium
    19 S. Manassas
    Memphis, TN usa 38163


    Browse Events At This Location
    Contact:
    Terry Mark-Major
    Email: Phone: 8-2656
    Share this Event
    facebook twitter google+ Bookmark this on del.icio.us Submit this to digg reddit
     Email to a Friend

    Save to Your Calendar
     Google Calendar
     Yahoo! Calendar
     iCal (download) (subscribe)
     Outlook (vCalendar)


     

    < >
    S M T W T F S
        01 02 03 04 05
    06 07 08 09 10 11 12
    13 14 15 16 17 18 19
    20 21 22 23 24 25 26
    27 28 29 30 31